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Live, attenuated vaccines


A) include the Sabin polio vaccine.
B) include the measles, mumps, rubella vaccine (MMR) .
C) contain viable microbes that can multiply in the person.
D) require smaller doses and fewer boosters compared to inactivated vaccines.
E) All of the choices are correct.

F) A) and C)
G) B) and E)

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Which of the following conditions have been conclusively proven to be linked to childhood vaccinations?


A) Autism
B) Diabetes
C) Asthma
D) All of the choices are correct.
E) None of the choices are correct.

F) None of the above
G) B) and E)

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Vaccinia virus is often used in the technique to make


A) adjuvant.
B) booster.
C) antibodies to toxin.
D) gamma globulin.
E) "Trojan horse" recombinant vaccine.

F) All of the above
G) A) and B)

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The DTaP immunization


A) contains diphtheria toxoid.
B) is administered in childhood.
C) contains tetanus toxoid.
D) contains a pertussis vaccine with acellular capsule material.
E) All of the choices are correct.

F) D) and E)
G) C) and D)

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All of the following are characteristics of an effective vaccine except


A) it should have a relatively long shelf life.
B) it should stimulate only the antibody (B-cell) response.
C) it should protect against wild forms of the pathogen.
D) it should not require numerous boosters.
E) it should be easy to administer.

F) A) and B)
G) B) and C)

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Killed or inactivated vaccines are prepared by


A) removal of virulence genes from the microbe.
B) treatment with formalin, heat, or radiation.
C) passage of the pathogen through unnatural hosts or tissue culture.
D) long-term subculturing of the microbe.
E) All of the choices are correct.

F) B) and D)
G) None of the above

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Cody is 4 months old and is given an MMR injection by his pediatrician as part of the routine immunization schedule.What type of immunity is this?


A) Natural active immunity
B) Artificial passive immunity
C) Natural passive immunity
D) Artificial active immunity
E) None of the choices will protect him.

F) A) and C)
G) C) and D)

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The major histocompatability complex is


A) a group of blood vessels that protects the nervous system.
B) a set of genes that code for MHC cell receptors.
C) also known as the complement system.
D) located in the thymus gland.
E) all of the choices are correct.

F) D) and E)
G) A) and E)

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Which kind of T cell synthesizes perforins and granzymes to destroy bacteria, viral infected cells, and cancer cells?


A) TC
B) TH
C) CD4
D) MHC

E) C) and D)
F) None of the above

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Autoantigens are types of antigens that cause damage to host tissue as a consequence of the immune response.

A) True
B) False

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Gamma globulin can be given as immunotherapy to confer artificial passive immunity.

A) True
B) False

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Herceptin is an example of a monoclonal antibody-based drug for


A) asthma.
B) Chron's disease.
C) breast cancer.
D) respiratory syncytial virus.
E) All of the choices are correct.

F) All of the above
G) None of the above

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_____ is the most abundant class of antibodies in serum.

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In the primary response to an antigen, the first class of antibody to be secreted is


A) IgD.
B) IgE.
C) IgG.
D) IgM.
E) IgA.

F) A) and E)
G) D) and E)

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All of the following are advantages of attenuated vaccines over inactivated vaccines except


A) they require smaller doses.
B) they require fewer boosters.
C) they confer longer lasting protection.
D) they can be transmitted to other people.
E) they produce infection but not disease.

F) A) and C)
G) A) and D)

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Small foreign molecules that are too small by themselves to elicit an immune response are termed


A) antigenic determinant.
B) hapten.
C) antigen binding site.
D) variable region.
E) None of the choices are correct.

F) None of the above
G) A) and B)

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An example of artificial passive immunity would be


A) chickenpox infection is followed by lifelong immunity.
B) chickenpox vaccine triggers extended immunity to chickenpox.
C) giving a person immune serum globulins to chickenpox virus after exposure to the disease.
D) a fetus acquiring maternal IgG to the chickenpox virus across the placenta.
E) None of the choices are correct.

F) C) and D)
G) A) and B)

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High titers of specific antibodies are components of


A) specific immune globulin (SIG) .
B) gamma globulin.
C) immune serum globulin (ISG) .
D) attenuated vaccines.
E) toxoids.

F) A) and B)
G) A) and E)

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Reliable vaccines exist for all of the following diseases except


A) malaria.
B) botulism.
C) cholera.
D) yellow fever.
E) rabies.

F) A) and C)
G) B) and C)

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Acellular vaccines and subunit vaccines


A) contain modified bacterial exotoxin molecules.
B) are always genetically engineered.
C) contain select antigenic components of a pathogen rather than whole cells or viruses.
D) confer passive immunity.
E) All of the choices are correct.

F) C) and D)
G) A) and E)

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