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___________ are a type of internal signal molecule used in controlling the cell cycle.


A) Kinases
B) Histones
C) Centromeres
D) Actins
E) Nucleosomes

F) B) and E)
G) A) and B)

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All of the following statements are true about mitosis except


A) the cells arising from the process are genetically alike.
B) the process of mitosis is followed by cytokinesis.
C) spindle fibers are involved in the movement of chromosomes.
D) both sexually and asexually reproducing organisms utilize the process of mitosis.
E) the cells arising from the process contain only half of the necessary genetic material.

F) C) and E)
G) B) and D)

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The spindle serves two rolls in mitotic cell division.These are


A) to separate the sister chromatids and to elongate the cell.
B) to separate the non-sister chromatids and then the homologous chromosomes.
C) to separate the sister chromatids and then the non-sister chromatids.
D) to separate the sister chromatids and then form the cleavage furrow.
E) to separate the homologous chromosomes and then form the cleavage furrow.

F) C) and E)
G) A) and B)

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Unicellular organisms undergo mitotic division to


A) repair damaged cells.
B) increase the size of the organism.
C) produce new organisms.
D) increase the genetic variability of the population.
E) produce gametes.

F) B) and E)
G) A) and D)

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Proteins that are involved in the regulation of the cell cycle,and that show fluctuation in concentration during the cell cycle,are called


A) centromeres.
B) kinetochores.
C) centrioles.
D) proton pumps.
E) cyclins.

F) B) and E)
G) C) and E)

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An oncogene is more likely to lead to cancer than a mutant tumor suppressor because


A) a gain of function mutation in an oncogene need only occur in one allele before it disrupts control of the cell cycle.
B) a loss of function mutation in an oncogene is sufficient to cause unregulated cell division.
C) the mutant oncogene may inactivate telomerase.
D) a gain of function mutation in a tumor suppressor gene can promote the cell cycle.
E) a gain of function mutation in an oncogene is more likely to cause the other allele to mutate.

F) A) and E)
G) B) and E)

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If a cell stops at the G1 checkpoint,this is most likely due to what problem?


A) There is DNA damage.
B) The DNA has not finished replicating.
C) The chromosomes are not aligned properly.
D) The cell is cancerous.
E) There is no problem. The cell normally stops at the G1 checkpoint.

F) A) and B)
G) D) and E)

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A translocation may lead to cancer if it


A) disrupts control of expression of genes that regulate the cell cycle.
B) deletes the telomere of the chromosome.
C) moves genes from one chromosome to another.
D) activates tumor suppressor genes.
E) affects both tumor suppressor and proto-oncogenes.

F) A) and C)
G) B) and E)

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In the absence of growth factors,the retinoblastoma (RB) protein binds a transcription activator called E2F,preventing the cell from entering S stage.A mutation in E2F occurs that causes RB to no longer bind it.This mutant E2F would be considered a(n)


A) oncogene.
B) proto-oncogene.
C) tumor supressor.
D) gain-of-function mutant.
E) growth factor.

F) A) and D)
G) A) and C)

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Proto-oncogenes function by preventing cells from dividing uncontrollably.

A) True
B) False

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If there are twenty centromeres in a cell,how many chromosomes are there?


A) 10
B) 20
C) 30
D) 40
E) 80

F) A) and D)
G) A) and C)

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Cancer is a disorder in which some cells have lost the ability to control their


A) size.
B) spindle fibers.
C) growth rate.
D) surface area.
E) volume.

F) All of the above
G) A) and B)

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Ben was looking at onion root tip cells under the microscope in Biology class.He saw one cell that had two nuclei within it.What stage of the cell cycle was this cell in?


A) anaphase
B) interphase
C) metaphase
D) prophase
E) telophase/cytokinesis

F) A) and D)
G) B) and C)

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A mutation results in a cell that no longer produces a normal protein kinase for the M-phase checkpoint.Which of the following would likely be the immediate result of this mutation?


A) The cell would prematurely enter anaphase.
B) The cell would never leave metaphase.
C) The cell would never enter metaphase.
D) The cell would never enter prophase.
E) The cell would undergo normal mitosis, but fail to enter the next G1.

F) A) and E)
G) None of the above

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Which of the following statements is correct regarding the events of the cell cycle?


A) DNA is duplicated during the G1 and G2 phases.
B) DNA replicates during cytokinesis.
C) The M phase is usually the longest phase.
D) Interphase consists of G1, S, and G2.
E) The cell stops growing in G2 phase.

F) A) and B)
G) B) and D)

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Cytokinesis in plants occurs as _______________ and in animals as ________________.


A) actin fibers pull the membrane inward until the two sides touch; the Golgi apparatus produces membrane bound vesicles filled with materials to make the cell wall.
B) the Golgi apparatus produces membrane bound vesicles filled with materials to make the cell wall; actin fibers pull the membrane inward until the two sides touch.
C) the centrosome produces membrane bound vesicles filled with materials to make the cell wall; the Golgi apparatus produces actin fibers to pull the membrane inward until the two sides touch.
D) actin fibers interact to make the cell wall; the cleavage furrow pulls the membrane inward until the two sides touch.
E) the Golgi apparatus produces a cleavage furrow; actin fibers pull the membrane inward until the two sides touch.

F) C) and E)
G) A) and D)

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Which of the following is not a characteristic of cancer cells?


A) cells that have lost contact inhibition
B) cells with abnormal nuclei
C) cells which function normally for tissue they are in
D) cells that lack differentiation
E) cells that have uncontrolled cell division

F) D) and E)
G) All of the above

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A mutation that causes a gain of function in a tumor suppressor gene would not likely cause cancer because a tumor suppressor protein


A) normally promotes the cell cycle.
B) normally responds to growth factors.
C) activates a signal transduction pathway.
D) inactivates growth factors.
E) does not promote cell division.

F) A) and B)
G) D) and E)

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When during the cell cycle are chromosomes visible?


A) only during interphase
B) only when they are being copied
C) during Mitosis
D) only during the G1 phase
E) Chromosomes are always visible

F) C) and E)
G) All of the above

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Which of the following organelles would be abundant and in close proximity to the cell plate in a plant cell undergoing cytokinesis?


A) centrioles
B) Golgi apparatus
C) rough endoplasmic reticulum
D) lysosomes
E) central vacuole

F) B) and C)
G) B) and D)

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