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Which of the following statements about hematopoietic stem cell transplantation is false?


A) It involves pluripotent stem cells.
B) It uses the patient's own stem cells.
C) It is used because some treatments against cancer also kill hematopoietic cells.
D) It leads to the production of both red and white blood cells.
E) All of the above are true; none is false.

F) B) and D)
G) All of the above

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Describe one application for human health of multipotent stem cells and one application for human health of cloned mammals.

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Hematopoietic stem cells are multipotent...

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Cell differentiation


A) results from the loss of particular genes from the nucleus of the differentiated cell.
B) results from the differential expression of genes that are responsive to environmental signals.
C) involves the persisting totipotency of early embryonic cells in the mature organism.
D) results from mutations in genes that control the synthesis of DNA.
E) precedes cell determination.

F) A) and B)
G) A) and C)

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Which of the following statements about plant development is false?


A) Both cell division and cell expansion contribute to growth in early plant embryos.
B) Differentiation in plant cells is irreversible.
C) Meristems at the tips of the roots and stems consist of undifferentiated cells.
D) Flower development in a plant involves organ identity genes.
E) In plants, the fertilized egg is called a zygote.

F) B) and E)
G) C) and D)

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The primary inducer of the vulva in C. elegans comes from the _______ cell.


A) primary vulval precursor
B) lens placode
C) homeotic
D) anchor
E) None of the above

F) C) and D)
G) None of the above

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Female Drosophila that are homozygous for the bicoid maternal effect gene mutation produce larvae with no head or thorax. When cytoplasm from the anterior end of a wild-type egg is inoculated into the anterior end of a bicoid mutant egg, the treated egg develops normally. What causes the restoration of normal development in the mutant eggs?


A) Disruption of mutant bicoid gene expression after their inoculation with wild-type egg cytoplasm
B) Normal bicoid gene expression
C) Expression of the nanos gene
D) Induction of normal development by adjacent embryo cells
E) The inoculation of normal egg cytoplasm

F) B) and E)
G) None of the above

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Hox genes, as well as some other types of genes that encode transcription factors, all have a 180-base-pair sequence known as the _______, which encodes a 60-amino-acid sequence known as the _______.

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homeobox; ...

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Which of the following statements about cloned animals is true?


A) Cloned pets will have the same behavioral characteristics as the original pet.
B) Cloning has been used to preserve endangered species.
C) Cloning has been used in conjunction with recombinant DNA technology for commercial purposes.
D) Both a and b
E) Both b and c

F) A) and B)
G) A) and C)

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Use the following to answer questions: The diagram below shows different patterns of expression in a Drosophila embryo. Use the following to answer questions: The diagram below shows different patterns of expression in a Drosophila embryo.   -A different developmental gene shows the pattern of expression in a Drosophila embryo as shown by part B in the diagram above. Based on this information, this gene most likely belongs to the _______ class of genes. A)  gap B)  Hox C)  segment polarity D)  MADS box E)  pair rule -A different developmental gene shows the pattern of expression in a Drosophila embryo as shown by part B in the diagram above. Based on this information, this gene most likely belongs to the _______ class of genes.


A) gap
B) Hox
C) segment polarity
D) MADS box
E) pair rule

F) A) and B)
G) A) and E)

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Nucleic acid hybridization was used to test which of the following hypotheses about Hox genes?


A) Hox genes are transcription factors.
B) Hox genes were derived from duplications of a single ancestral gene.
C) Hox genes are responsible for the identity of segments in the developing embryo.
D) Hox genes are maternal effect genes.
E) Hox genes encode morphogens.

F) C) and E)
G) A) and E)

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Which of the following distinguishes the developmental cascade seen in Drosophila melanogaster from a signal transduction cascade?


A) Transcription factors are involved only in the signal transduction cascade.
B) Transcription factors are involved only in the developmental cascade.
C) The signal transduction cascade occurs mainly within a single cell.
D) The signal transduction cascade takes place over a much longer period of time.
E) Protein kinases are found only in the signal transduction cascade.

F) B) and C)
G) D) and E)

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Differentiated cells in the process of forming the liver of a mouse provide an example of


A) differentiation.
B) determination.
C) apoptosis.
D) induction.
E) morphogenesis.

F) C) and D)
G) B) and E)

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In the first successful cloning of a sheep, cells from the ewe's udder were modified to become appropriate donor cells. In order for these udder cells to be suitable donor cells, they were


A) arrested in the G1 phase of the cell cycle.
B) arrested in the G2 phase of the cell cycle.
C) supplied with extra nutrients.
D) Both a and c
E) Both b and c

F) B) and D)
G) B) and E)

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Using the information in the graph below, draw a diagram showing the concentration of nanos and bicoid mRNA in a Drosophila embryo from the anterior to the posterior ends. Using the information in the graph below, draw a diagram showing the concentration of nanos and bicoid mRNA in a Drosophila embryo from the anterior to the posterior ends.

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Which of the following is a technique that can be used to show genomic equivalence?


A) RNAi
B) Nucleic acid hybridization
C) Induction
D) Two-dimensional gel electrophoresis
E) RFLP mapping

F) A) and B)
G) A) and E)

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Which statement about determination is true?


A) Differentiation precedes determination.
B) All cells are determined after two cell divisions in most organisms.
C) A determined cell will keep its determination no matter where it is placed in an embryo.
D) A cell changes its appearance when it becomes determined.
E) A differentiated cell has the same pattern of transcription as a determined cell.

F) B) and E)
G) A) and E)

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Which of the following classes of pattern formation genes is responsible for organizing broad areas along the anterior-posterior axis?


A) Maternal effect genes
B) Gap genes
C) Pair rule genes
D) Segment polarity genes
E) Hox genes

F) A) and B)
G) D) and E)

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Use the following to answer questions: The diagram below shows experiments performed to determine whether the fates of cells are irrevocably determined. Use the following to answer questions: The diagram below shows experiments performed to determine whether the fates of cells are irrevocably determined.   -If cell fate were not irrevocably determined, and skin tissue could develop into notochord tissue but not into brain tissue, a normal embryo would develop in A)  Experiment 1 only. B)  Experiment 2 only. C)  Experiment 3 only. D)  Experiments 1 and 2. E)  Experiments 2 and 3. -If cell fate were not irrevocably determined, and skin tissue could develop into notochord tissue but not into brain tissue, a normal embryo would develop in


A) Experiment 1 only.
B) Experiment 2 only.
C) Experiment 3 only.
D) Experiments 1 and 2.
E) Experiments 2 and 3.

F) B) and D)
G) D) and E)

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The gene _______ encodes a transcription factor involved in the conversion of undifferentiated muscle precursor cells called _______ into muscle fibers.

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Experiments have shown that fully differentiated cells still contain all their genes, even though they express only a small set of those genes. Which type of hybridizations have demonstrated this? How do such hybridizations work?

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Hybridizations were carried out using a ...

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